DMOG,89464-63-1,IC-0220559

DMOG(dihydroxyalanine) is an antagonist of α-ketoglutarate cofactor and an inhibitor of HIF-proline hydroxylase, leading to the stability and accumulation of HIF-1α protein in the nucleus[4].

DMOG reduce susceptibility to endotoxemia by tolerating cells to LPS activation and promoting M2 polarization and subsequent up-regulation of IL-10 by peritoneal B1 cells[1]. DMOG inhibited hydroxyproline synthesis from chick embryo lung, with IC50 values of 9.3 μM and 3.7 μM corresponding to tissue and medium sources, respectively[2].The combination of DMOG and nSi exerted admirable effects on periodontal tissue regeneration. DMOG/nSi-PLGA fibrous membranes could enhance and orchestrate osteogenesis-angiogenesis[4].Inhibition of hydroxylase by oxygen sensing leads to upregulation of the transcription factors HIF-1α and NF-β under normal oxygen in vitro,0.1 to 1mM DMOG can stabilize the expression of HIF-1α[3].DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC[8]. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[5][6]. DMOG induces cell autophagy and protect cells from a subsequent OGD insult.[7].

DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice[5]. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats[6].