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Product Details
3-Indolepropionic acid,830-96-6,IC-0112012
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities.1,2,3 It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 ?M and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 ?M).2 Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells.4 It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.3
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities.1,2,3 It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 ?M and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 ?M).2 Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells.4 It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.3
