Forskolin,66575-29-9,IC-0197690

Forskolin is a potent adenylyl cyclase activator with IC50 of 41 nM for type I adenylyl cyclase [1]. Forskolin, with EC50 of 0.5 μM, is also an inducer of intracellular cAMP formation [2] Forskolin induces the differentiation of a variety of cells, activates progesterone X receptor (PXR) and FXR[3] Forskolin has contractile effects on the heart, and has anti-platelet aggregation and antihypertensive effectsForskolin also induces autophagy [4][5].
Forskolin (Coleonol) is also a potent exosome biogenesis and/or secretion activator in prostate cancer (PC) cells[7]. Modulation of free radical stress in human red blood cell membrane by forskolin and the prospects for treatment of cardiovascular disease and Diabetes[8].The increase in cAMP by forskolin attenuated cytotoxicity and apoptosis.
In vivo studies，forskolin predominantly decreased basal glucose in healthy rats and attenuated the severity of hyperglycemia in diabetic rats[6]. The Mrp4(-/-) mice exhibited no overt abnormalities in the development of the retinal vasculature, but retinal vascular development in the Mrp4(-/-) mice was suppressed in response to forskolin administration.The forskolin-treated Mrp4(-/-) mice showed an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves[2].