(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis[1-2]. EGCG has free radical scavenging properties[3]. EGCG has anti-inflammatory and anti-apoptotic effects against oxidative stress in neurons[4].In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) [5]. (-)- Epigallocatechin Gallate(EGCG) (200 µM; 1 h) downregulates expression levels of pro-inflammatory cytokine and mediators in CoCl2-treated BV2 cells[6]. EGCG inhibits 3T3-L1 cell growth via miR-143/MAPK7 pathway[7]. (-)- Epigallocatechin Gallate(EGCG) (5 -30 mg/kg; i.g; 14 days) reduces tumor(HT-29 colorectal cancer) growth[8]. EGCG treatment(50 mg/kg per day) dissolved in corn oil was administrated via intraperitoneal injection from day 7 to 11 at 1 h before house dust mite (HDM) challenge) relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages[9].
(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis[1-2]. EGCG has free radical scavenging properties[3]. EGCG has anti-inflammatory and anti-apoptotic effects against oxidative stress in neurons[4].In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) [5]. (-)- Epigallocatechin Gallate(EGCG) (200 µM; 1 h) downregulates expression levels of pro-inflammatory cytokine and mediators in CoCl2-treated BV2 cells[6]. EGCG inhibits 3T3-L1 cell growth via miR-143/MAPK7 pathway[7]. (-)- Epigallocatechin Gallate(EGCG) (5 -30 mg/kg; i.g; 14 days) reduces tumor(HT-29 colorectal cancer) growth[8]. EGCG treatment(50 mg/kg per day) dissolved in corn oil was administrated via intraperitoneal injection from day 7 to 11 at 1 h before house dust mite (HDM) challenge) relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages[9].
